Insights into the role of the habenular circadian clock in addiction

Insights into the role of the habenular circadian clock in addiction

Blog Article

Drug addiction is a brain disease involving alterations in anatomy and functional neural communication.Drug intake Comparison of Parameters and Fitness of Different Time-dependent and Time-Independent Independent Variables in Survival Analysis and toxicity show daily rhythms in both humans and rodents.Evidence concerning the role of clock genes in drug intake has been previously reported.

However, the implication of a timekeeping brain locus is much less known.The epithalamic lateral habenula (LHb) is now emerging as a key nucleus in drug intake and addiction.This brain structure modulates the activity of dopaminergic neurons from the ventral tegmental area, a central part of the reward system.

Moreover, the LHb has circadian properties: LHb cellular activity (i.e., firing rate and clock genes expression) oscillates in a 24h range, and the nucleus is affected by photic stimulation and has anatomical connections with the main circadian pacemaker, the Conflict Resolution between Multi-Level Government and Farmers in Land Expropriation Based on Institutional Credibility Theory: Empirical Evidence from Shandong Province, China suprachiasmatic nucleus.

Here, we describe the current insights on the role of the LHb as a circadian oscillator and its possible implications on the rhythmic regulation of the dopaminergic activity and drug intake.This data could inspire new strategies to treat drug addiction, considering circadian timing as a principal factor.